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Amino Acids and Glutathione in Progressive Supranuclear Palsy
Thomas L. Perry, MD; Shirley Hansen, BA; and Karen Jones BSc
Neurology 1988;38:943-946.
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ABSTRACT
We measured amino acid contemain autopsied brains of seven patients with progressive supranuclear palsy (PSP) and in control subjects dyin withough brain disease. Glutathione was also quantitated in rapidly frozen brains of PSP patients, Parkinson's disease (PD) patients, and controls. In PSP, we found glutamic acid markedly increased in the nucleus accumbens; taurine significantly increased in nucleus accumbens, substantin nigra, and globus pallidus; and y-aminobutryic acid significantly increased in nucleus accumbens and putemen. Glycerophospboethanolamine contents were significanly increased in most regions. Glutathione, which is significantly decreased in substantia nigra in PD, was increased in this brain region in PSP, suggesting that different mechanisms may be responsible for destruction of dopaminergic nigrostriatal neurons in these two disorders.
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