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Glutathione Articles - Cardiovascular Disease
Relationship Between Oxidative Stress and Essential Hypertension
Rodrigo R, Prat H, Passalacqua W, Araya J,
Guichard C, Bächler JP
Hypertens Res. 2007 Dec;30 (12):1159-67
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ABSTRACT
This study investigated the
association of blood pressure with blood oxidative stress related
parameters in normotensive and hypertensive subjects. A cross-sectional
design was applied to 31 hypertensive patients and 35 healthy
normotensive subjects. All subjects were men between the ages of 35 and
60 years. Exclusion criteria were obesity, dyslipidemia, diabetes
mellitus, smoking and current use of any medication. All patients
underwent 24-h ambulatory blood pressure monitoring and sampling of
blood and urine. Antioxidant enzymes activity, reduced/oxidized
glutathione ratio (GSH/GSSG), and lipid peroxidation (malondialdehyde)
were determined in erythrocytes. Parameters measured in the plasma of
test subjects were plasma antioxidant status, lipid peroxidation
(8-isoprostane), plasma vitamin C and E, and the blood pressure
modulators renin, aldosterone, endothelin-1 and homocysteine. Daytime
systolic and diastolic blood
pressures of hypertensives were negatively correlated with plasma
antioxidant capacity (r=-0.46, p<0.009 and r=-0.48, p<0.007), plasma
vitamin C levels (r=-0.53, p<0.003 and r=-0.44, p<0.02), erythrocyte
activity of antioxidant enzymes, and erythrocyte GSH/GSSG ratio, with
hypertensives showing higher levels of oxidative stress. Blood pressures
showed a positive correlation with both plasma and urine 8-isoprostane.
Neither plasma vitamin E nor the assessed blood pressure modulator
levels showed significant differences between the groups or correlation
with blood pressures. These findings demonstrate a strong association
between blood pressure and some oxidative stress related parameters and
suggest a possible role of oxidative stress in the pathophysiology.
of essential hypertension.
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