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Safety and Efficacy of Oral DMSA Therapy for Children with
Autism Spectrum Disorders: Part A - Medical Results
James B. Adams, Matthew Baral, Elizabeth
Geis, Jessica Mitchell, Julie Ingram, Andrea Hensley, Irene Zappia,
Sanford Newmark, Eva Gehn, Robert A Rubin, Ken Mitchell, Jeff Bradstreet
and Jane El-Dahr
BMC Clinical Pharmacology 2009, 9:16doi:10.1186/1472-6904-9-16
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BACKGROUND:
This study investigated the effect of oral dimercaptosuccinic acid
(DMSA) therapy for children with autism spectrum disorders ages 3-8
years.
METHODS:
Phase 1 involved 65 children who received one round of DMSA (3 days).
Participants who had high urinary excretion of toxic metals were
selected to continue on to phase 2. In phase 2, 49 participants were
randomly assigned in a double-blind design to receive an additional 6
rounds of either DMSA or placebo.
RESULTS:
DMSA greatly increased the excretion of lead, substantially increased
excretion of tin and bismuth, and somewhat increased the excretion of
thallium, mercury, antimony, and tungsten. There was some increase in
urinary excretion of essential minerals, especially potassium and
chromium. The Phase 1 single round of DMSA led to a dramatic
normalization of RBC glutathione in almost all cases, and greatly
improved abnormal platelet counts, suggesting a significant decrease in
inflammation.
CONCLUSIONS:
Overall, DMSA therapy seems to be reasonably safe, effective in removing
several toxic metals (especially lead), dramatically effective in
normalizing RBC glutathione, and effective in normalizing platelet
counts. Only 1 round (3 days) was sufficient to improve glutathione and
platelets. Additional rounds increased excretion of toxic metals.
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