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Glutathione Articles - ASD (Autism Spectrum Disorders)
Autism: A Multi-System Oxidative and Inflammatory Disorder
Townsend Letter; Issue 297, April 2008, p86-90..
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An excerpt from Autism: A Multi-System Oxidative and Inflammatory Disorder:
“The Autism is a complex, multifactorial disorder of uncertain etiology. Initially described as a psychological disorder involving communication failure, repetitive behavior, autism is associated with measurable defects in many organ systems. Neurotransmitter, enzymatic, and structural abnormalities have been observed in the nervous system. Autoimmunity is common, as are loss of gut integrity and coagulation abnormalities. At a metabolic level, not only is mitochondrial function seriously impaired, but also numerous enzymes and substrates are deficient in quantity or activity. Various therapies addressing isolated metabolic impairments have shown partial benefit in limited subgroups.
The complex range of stigmata seen in autism is consistent with a pathological state of oxidative stress and inflammation. Various therapies addressing oxidative stress and inflammation have had some success and are reviewed here. We postulate that effective strategies dealing with the primary causative sources of oxidative stress can result in definitive resolution of many of the symptoms associated with the autism spectrum disorder. Suggestions are made for future therapeutic modalities addressing possible underlying causes of oxidative stress."
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