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inhibition of influenza infection by glutathione
Glutathione Articles - Additional Usages
Inhibition of influenza infection by glutathione
Cai J, Chen Y, Seth S, Furukawa S, Compans RW & Jones DP
Free Radic Biol Med. 2003 Apr 1:34(7):928-36.
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ABSTRACT
Infection by RNA virus induces
oxidative stress in host cells. Accumulating evidence suggests that
cellular redox status plays an important role in regulating viral
replication and infectivity. In this study, experiments were performed to
determine whether the thiol antioxidant glutathione (GSH) blocked
influenza viral infection in cultures of Madin-Darby canine kidney cells
or human small airway epithelial cells. Protection against production of
active virus particles was observed at a low (0.05-0.1) multiplicity of
infection (MOI). GSH inhibited expression of viral matrix protein and
inhibited virally induced caspase activation and Fas upregulation. In BALB/c
mice, inclusion of GSH in the drinking water decreased viral titer in both
lung and trachea homogenates 4 d after intranasal inoculation with a
mouse-adapted influenza strain A/X-31. Together, the data suggest that the
thiol antioxidant GSH has an anti-influenza activity in vitro and in vivo.
Oxidative stress or other conditions that deplete GSH in the epithelium of
the oral, nasal, and upper airway may, therefore, enhance susceptibility
to influenza infection.
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