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Effect of Glutathione Administration on Serum Levels of
Reactive Oxygen Metabolites in Patients with Paraquat Intoxication: A
Pilot Study
Jung-Hoon Kim, Hyo-Wook Gil, Jong-Oh Yang, Eun-Young
Lee, and Sae-Yong Hong
Korean J Intern Med 2010;25:282-287
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Background: Based on
preliminary in vitro data from a previous study, we proposed that 50
mg/kg
glutathione (GSH) would be adequate for suppressing reactive oxygen
species in patients with acute paraquat
(PQ) intoxication.
Methods: Serum levels of reactive oxygen metabolites (ROM) were measured
before and after the administration
of 50 mg/kg GSH to each of five patients with acute PQ intoxication.
Results: In one patient, extremely high pretreatment ROM levels began to
decrease prior to GSH administration.
However, in the remaining four cases, ROM levels did not change
significantly prior to GSH administration. ROM
levels decreased significantly after GSH administration in all cases. In
two cases, ROM levels decreased below
that observed in the general population; one of these patients died
after a cardiac arrest at 3 hours after PQ
ingestion, while the other represented the sole survivor of PQ
intoxication observed in this study. In the survivor,
ROM levels decreased during the first 8 hours of GSH treatment, and
finally dropped below the mean ROM level
observed in the general population.
Conclusions: Treatment with 50 mg/kg GSH significantly suppressed serum
ROM levels in PQ-intoxicated
patients. However, this dose was not sufficient to suppress ROM levels
when the PQ concentration was extremely
high.
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