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Glutathione Articles - Additional Usages
Glutathione Blood Levels and Other Oxidant Defense Indices
in Men Fed Diets Low in Vitamin C
Henning SM, Zhang, JZ, McKee RW, Swendseid ME,
and Jacob, RA
The Journal of Nutrition 121: 1969-1975, 1991.
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Because ascorbic acid is an
important contributor to the oxidant defense system in body tissues, we
studied the effects of a low dietary intake of
ascorbic acid on various indicators of oxidant defenseand oxidant
damage. During a 13-wk study eight healthy men (25-43 y), residing in a
live-in metabolic unit, were fed controlled diets containing different
amounts of ascorbic acid for four consecutive periods: period 1 -250
mg/d for 4 d; period 2-5 mg/d for 32 d; period 3 - 10 or 20 mg/d for 28
d and period 4 - 60 or 250 mg/d for 28 d. Measurements were made at
several time intervals of the activities of giutathione peroxidase and
Superoxide disimilase in RBC, DMA strand breaks in mononuclear
leucocytes, giutathione concentrations in
plasma and RBC and NAD and NADP in RBC. After 60 d of low ascorbic acid
intakes and associated with plasma ascorbic acid levels <6 |imol/L, the
total giutathione concentration and the reduced glutathione:oxidized
giutathione ratio were decreased in plasma. At the same time NAD and
NADP levels in RBC were elevated. It seems that chronic marginal vitamin
C deficiency states may be associated with selected biochemical changes
in oxidant defense indices
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