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Glutathione Articles - Additional Usages
Adaptive stress
response of glutathione and uric acid metabolism in man following
controlled exercise and diet
Svensson MB, Ekblom B, Cotgreave IA, Norman B, Sjöberg B, Ekblom O, Sjödin
B, Sjödin A.
Acta Physiol Scand. 2002 Sep;176(1):43-56.
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ABSTRACT
Ergometer cycling performance
as well as acute exercise-induced changes in the metabolism of
energy-intermediates and glutathione (GSH) were investigated in skeletal
muscle (SM) of 15 healthy young male subjects (VO(2max) approximately
54.7 mL kg(-1) min(-1), age approximately 25 years), before and after 3
days of controlled 'ìoverloadtraining' in combination with either high
(62% of energy intake) or low (26% of energy intake) dietary intake of
carbohydrates. The intake of a carbohydrate-rich diet clearly reduced
the depletion of SM glycogen following the short-term training period,
paralleled with a positive effect on the endurance performance, but not
on high-intensity work performance. An 'delayed over-reaching effect',
defined as impaired work-performance, was observed after 2.5 days of
recovery from the short-term training period, irrespective of the
carbohydrate content of the diet and basal glycogen level in SM. Taken
together, the main and novel findings of present investigation are: (1)
an acute decrease of reduced GSH content and altered thiol-redox
homeostasis in SM induced by strenuous high intensity exercise; (2) an
adaptive elevation of basal GSH level following the short-term training
period; (3) an adaptive decrease of basal GSH level following 2.5 days
recovery from training; (4) evidence of a relationship between the SM
fibre type, physical performance capacity and GSH turnover during acute
bouts of exercise; and (5) no evident effect of the level of
carbohydrate intake on metabolism of GSH or energy intermediates.
Furthermore, the induction of acute oxidative stress in exercising human
SM and the adaptive responses to training are suggested to provide a
protective antioxidant phenotype to the exercising SM during periods
with repeated intense intermittent training.
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