home > articles > additional usages > effect of glutathione infusion on leg arterial circulation, cutaneous microcirculation, and pain-free walking distance in patients with peripheral obstructive arterial disease: a randomized, double-blind, placebo-controlled trial
Glutathione Articles - Additional Usages
Effect of
Glutathione Infusion on Leg Arterial Circulation, Cutaneous
Microcirculation, and Pain-Free Walking Distance in Patients With
Peripheral Obstructive Arterial Disease: A Randomized, Double-Blind,
Placebo-Controlled Trial
Arosio, Enrico, MD; De Marchi, Sergio, MD; Zannoni, Massimo, Prior, MD;
and Lechi, Alessandro, MD
Mayo Clin Proc. 2002; 77:754-759.
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ABSTRACT
Objective: To assess the
effects of glutathione on pain-free walking distance (PFWD) and
hemodynamic parameters in patients with peripheral artery disease.
Patients and Methods: Forty patients with Fontaine stage II
peripheral artery disease who were seen between September 2000 and March
2001 at the vascular laboratory and ward of the division of Vascular
Medicine and Rehabilitation at Verona University were studied in a
double-blind, placebo-controlled trial. The patients were randomly
assigned (20 per group_ to treatment with intra-venous glutathione twice a
day or saline solution twice a day for 5 days. Treatments were administered
in a double-blind manner. The 2 groups of patients underwent measurement of
PFWD by strain-gauge plethysmography and laser Doppler flowmetry with (postisehemic
test) of symptomatic leg at rest and after treadmill test. All
measurements and tests were repeated 12 hours after the last infusion.
Results: Between the 2 groups, hemodynamic tests showed no
differences in baseline values and at rest after treatment. At rest, no
differences were observed between basal and post treatment values;
findings in the saline group were similar during tests before and after
the infusion period. In the glutathione group, we observed increases in
PFWD (196±15 vs. 143±11 m; P<.04), macrocirculatory flow after treadmill
test with plethysmography at the end of treatment (9.3±2
vs. 2.8±0.5 mL
per 100 mL/min; P<.002), and postisehemic hyperemia with laser Doppler
flowmetry, registered as perfusion units (PU), at the end of infusions
(14.4±3.2 vs. 6.18±1.5 PU; P<.005), with a greater area under the curve
after treatment (705±103 vs. 508±5 PU/s; P<.001) and reduced time to
flow motion (32±4 vs. 48±11 seconds; P,.05).
Conclusion: In patients with peripheral artery disease, glutathione
prolongs PFWD and shows an improvement of macrocirculatory and
microcirculatory parameters.
Abbreviations: PFWD = pain-free walking distance;
PU = perfusion units
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