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Glutathione Articles - Acetaminophen Toxicity

Hepatoprotection by L-Cysteine-Glutathione Mixed Disulfide, a Sulfhydrylmodified Prodrug of Glutathione
Berkeley LI, Cohen JF, Crankshaw DL, Shirota FN and Nagasawa HT
J Biochem Mol Toxicol. 2003;17(2):95-7.
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ABSTRACT

L-Cysteine-glutathione disulfide, a ubiquitous substance present in mammalian cells, was shown to be highly effective in protecting mice against acetaminophen-induced hepatotoxicity. Since the corresponding D-cysteine-glutathione disulfide was totally ineffective in this regard, an enzymatic mechanism that provides glutathione directly to cells is postulated. Copyright 2003 Wiley Periodicals, Inc. J Biochem Mol Toxicol 17:95- 97, 2003; Published online in Wiley InterScience (www.interscience.wiley.com).

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